stigma-, stig-, stix- (Greek > Latin: mark, reproach [from Greek, "puncture, brand, mark, point"]).

The Greek "stigma" denoted a "mark made on the skin with a sharp implement," hence a "tattoo" or "brand." By the time it arrived in English, via Latin "stigma", it had acquired the connotation of a "brand of shame," and it was also used specifically for the marks made on Christ's hands and feet by the nails of the cross.