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acerbo-, acerb- (Latin: bitter, sharp, sour, stinging).

acerb, acerbic:
Having a bitter or sour taste; sharp or bitter in temper, mood, or expression.
To irritate or annoy.
Sharp pointed and slender, as a pine needle.
Sourness of taste, with bitterness and astringency, as of unripe fruit; harseness, bitterness, or severity; as, acerbity of temper, of language, or of pain.
An abnormal fear of sour or bitter tasting foods or liquids.
exacerbate, exacerbating : To increase the severity of, aggravate; to irritate.

Increase in the severity of a disease or any of its symptoms, as in a continuous fever.
exacerbescence, exacerbescent:
Showing violence or bitterness; an irritation.